مرکز منطقه ای اطلاع رساني علوم و فناوري - Comparison of Age, Endometrial Thickness and Body Mass Index in Progression of Malignancy in Post menopausal Bleeding Cases

Abstract :

Objective: In this study, we aimed to compare age, endometrial thickness (ET) and body mass index (BMI) in progression of malignancy with postmenopausal bleeding (PMB) . Material and Method: The clinical and pathological features of 168 patients with PMB were analyzed retrospectively. All cases age, gravida, parity, duration of menopause, BMI, ET values were recorded. Patients with chronic diseases such as hypertension, diabetes and mass in ovary were excluded from the study. SPSS 17.0 software was used for statistical analysis. Kruskal Wallis was performed for analysis of variance, for the parameters that were p 0.05, Mann-Whitney U test was used in comparison between groups. p 0.05 was considered significant. Results: Benign causes and endometrial cancer groups were included to study. Group 1 (n = 78): Patients with PMB caused by benign pathologies. Group 2 (n = 12): Endometrial cancer cases diagnosed at PMB. In comprasion with the G1 and G2, endometrial thickness and age had a significant relationship with the malignancy, but not with BMI. With increase at cases age and ET, there was an increase at the progression to malignancy. Although BMI increased in malignant group compared to the benign group, there were no statistically significant differences. Conclusion: Increase at menopause age, endometrial thickness and BMI, risk increases for malignancy. However, in our study, age and endometrial thickness are more decisive than body mass index in progression of malignancy in patients with PMB. Endometrial thickness should be measured at women in the menopausal and must be managed according to the results.