Author/Authors :
YILMAZ, Rahşan Harran Üniversitesi - Veteriner Fakültesi - Patoloji Anabilim Dalı, TURKEY , ÖZYILDIZ, Zafer Harran Üniversitesi - Veteriner Fakültesi - Patoloji Anabilim Dalı, Turkey , TEMMAOĞULLARI, Füsun Harran Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji Anabilim Dalı, TURKEY , HAYAT, Ali Harran Üniversitesi - Veteriner Fakültesi - Cerrahi Anabilim Dalı, TURKEY
Title Of Article :
The Effects of Rosemary (Rosemarinus officinalis) Extract on Wound Healing in Rabbits
Abstract :
In the present study, we examined the effects of 5% Rosemarinus officinalis (rosemary) extract on wound healing as compared to those of povidone-iodine and isotonic saline solution by daily visual observation, histopathological and statistical methods. Six male and six female New Zealand rabbits were used in the study. On dorsal aspect of each rabbits, experimentally 3.14 cm in diameter, three full-thickness wounds was constituted. One of these wounds received daily 5% rosemary extract, another one received 10% povidone-iodine solution and the last one received 0.9% isotonic saline solution containing the gauze tampon for control purposes. Size of each wound was measured on days 4, 7, 10 and 14 using a caliper and biopsies were taken from different regions in clockwise direction proceedingly. Wound healings were assessed histopathologically in terms of neutrophil and macrophage infiltration with fibrocyte and fibroblast proliferation, collagen deposition, epithelialization, and vascularization. The aim of this study was to investigate the effect of rosemary extract on wound healing compared to povidone-iodine and isotonic saline solution.
NaturalLanguageKeyword :
Histopathology , rabbit , Rosemarinus officinalis , wound healing
JournalTitle :
Fırat University Veterinary Journal Of Health Sciences
