Author/Authors
Karakus, Sevgi Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya, Turkey , Çoruh, Ufuk Ondokuz Mayis Üniversitesi - Egitim Fakültesi, Turkey , Barlas-Durgun, Bilgehan Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya, Turkey , Vázquez-López, Ezequiel M. Universidade de Vigo - Facultade de Ciencias-Química, Spain , Özbas-Turan, Suna Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya, Turkey , Akbuga, Jülide Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya, Turkey , Rollas, Sevim Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya, Turkey
Title Of Article
Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted- 1,3,4-thiadiazole derivatives
شماره ركورد
18690
Abstract
In this search, a series of 5-[4-(4-fluorobenzoylamino)phenyl]-2-substitutedamino- 1,3,4-thiadiazole ( 2a-g ) and 5-[4-(4-fluorobenzoylamino)phenyl]-4-substituted-2,4-dihydro- 3H-1,2,4-triazo-le-3-thione ( 3a-f ) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, 1H-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany].
From Page
84
NaturalLanguageKeyword
Cytotoxic activity , 1 , 2 , 4 , triazoline , 3 , thione , 2 , 5 , disubstituted , 1 , 3 , 4 , thiadiazole , mtt assay , x , ray crystallograpy
JournalTitle
Journal of Research in Pharmacy
To Page
90
JournalTitle
Journal of Research in Pharmacy
Link To Document