Author/Authors :
Ünsalan, Seda Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya AD, Turkey , Çikla, Pelin Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya AD, Turkey , Küçükgüzel, S. Güniz Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya AD, Turkey , Rollas, Sevim Marmara Üniversitesi - Eczacilik Fakültesi - Farmasötik Kimya AD, Turkey , Sahin, Fikrettin Yeditepe Üniversitesi - Mühendislik ve Mimarlik Fakiltesi - Genetik ve Biyomühendislik Bölümü, Turkey , Bayrak, Ömer Faruk Yeditepe Üniversitesi - Mühendislik ve Mimarlik Fakiltesi - Genetik ve Biyomühendislik Bölümü, Turkey
Abstract :
A series of novel triazene derivatives 1-3, 1a-3a were synthesized by the coupling of diazonium salts of amines (sulfaguanidine, sulfapyridine, sulfamethoxazole) with N-methylaniline / p-nitroaniline in acidic media. The structures of the synthesized compounds were confirmed by the spectral data (UV, IR, 1H-NMR, APCI-MS) and elemental analysis. The effects of all the compounds on A 549 and L 929 cell lines growth were investigated. The cytotoxic and antitumor activities of these compounds have not been in vitro aganist A 549 and L 929 cell lines.
NaturalLanguageKeyword :
Triazene , sulfonamide , prontosil , azo reduction
