Abacı, Güleser Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , Rollas, Sevim Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , Tatar, Esra Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey

Development of a New and Efficient Synthesis Method of 1,2,4-Triazole-5-Thione Derivatives

18753

3,4-Disubstituted-2,4-dihydro-5H-1,2,4-triazole-5-thiones were synthesized by a new one-pot, two-step synthesis method which was demonstrated to be superior than the current synthesis methods. The new method involves addition of alkyl/aryl isothiocyanates to substituted hydrazides in ethanol following the refluxing process of intermeadiate in 4N sodium hydroxide solution. According to our new synthesis procedure, reaction has gone to completion within 6 hours by higher product yields and reduced solvent usage.

181

1 , 2 , 4 , triazole , 5 , thione , synthesis , method development

Journal of Research in Pharmacy

186