Özdemir, Ahmet Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey

Synthesis and antimicrobial activity of some pyrazoline derivatives bearing amide moiety

18755

In the present study, a series of pyrazoline derivatives were synthesized. The chemical structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR and FAB+- MS spectral data and elemental analyses. The synthesized compounds were screened for their antimicrobial activities. All compounds exhibited the highest antibacterial activity against P. aeruginosa. All compounds except compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4- chlorophenyl)-2-pyrazoline and 1-(chloroacetyl)-3-(2-thienyl)-5-(3,4-methylenedioxyphenyl)- 2-pyrazoline are more effective than ketoconazole against C. albicans, whereas compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4-chlorophenyl)-2-pyrazoline, 1-(chloroacetyl)-3-(2-thienyl)- 5-(3,4-methylenedioxyphenyl)-2-pyrazoline and ketoconazole showed the same level of antifungal activity against C. albicans.

187

pyrazoline , amide , furan , thiophene , antimicrobial activity

Journal of Research in Pharmacy

192