Author/Authors :
Demircioğlu, Fatih Rize Recep Tayyip Erdoğan Üniversitesi - Eğitim ve Araştırma Hastanesi - Radyasyon Onkolojisi, Turkey , Pak, Yücel Gazi Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi, Turkey , Akmansu, Müge Gazi Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi, Turkey , Bora, Hüseyin Gazi Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi, Turkey
Abstract :
Objective: In this study the relevant factors that effects the treatment outcomes of patients like hormone receptor and c-erbB-2 was established. Methods: The overall and disease-free survival rates were evaluated in 640 breast cancer patients. The mean follow-up was 59,1 months. Overall and disease-free survival rates found by Kaplan-Meier method at SPSS version 16.0. Log-Rank test evaluated the prognostic factors impact. Results: In ER (+) and (-) patients 5 year overall survival rates was 85,7%, 71,2% (p 0,001), disease free survival rates was 79,9%, 63,7% (p 0,001) respectively; in PR (+) and (-) patients 5 year overall survival rates was 85,6%, 71,6% (p 0,001), disease free survival rates was 79,6%, 64,3% (p 0,001) respectively. ER and PR positivity were significantly increased overall and disease-free survival. In c-erbB-2 over-expression 5 year overall survival rates was 76,4%, 85,3% (p=0,002), disease free survival rates was 69,7%, 79,1% (p=0,012) according to (-) patients. The worst prognosis had shown in ER (-), PR (-), c-erbB-2 (+) patients. Conclusion: ER, PR and c-erbB-2 levels have great importance in breast cancer and must be well considered in patients follow-up.
NaturalLanguageKeyword :
Breast neoplasm , hormone receptor status , c , erbB , 2
