Author/Authors :
BALAMTEKİN, Necati Gülhane Askeri Tıp Akademisi (GATA) - Çocuk Sağlığı ve Hastalıkları A D, Turkey , EKSERT, Sami Gülhane Askeri Tıp Fakültesi - Anestezi ve Reanimasyon BD, Turkey , GÜLGÜN, Mustafa Gülhane Askeri Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Turkey , KARSLIOĞLU, Yıldırım Gülhane Askeri Tıp Akademisi (GATA), Turkey , KARAOĞLU, Abdülbaki Gülhane Askeri Tıp Akademisi (GATA) - Çocuk Sağlığı ve Hastalıkları AD, Turkey
Title Of Article :
Non-sendromic interlobular paucity appearing in adolesant age: Case report
Abstract :
Interlobular paucity (ILP) is a disease characterized lower cholestatic chanels as well as hepatocellular giant cell transformation or/and fibrosis. A 14 year-old boy was referred us for itching, jaundice and weight loss for 3 months. On examination, both sclera were icteric. Laboratory analysis revealed alanin aminotransferase 178 IU, aspartat amino transferase 89 IU, total/direct bilirubine:5.5/3.9 mg/dl, anti Hepatitis A Virus IgA and IgG negative, HBs Ag negative, anti HBs pozitive, anti HCV negative, AntiHIV negative, antinuclear antibody negative, anti double strand DNA negative, anti smooth muscle antibody negative, anti mitochondrial antibody negative and anti liver kidney antibody negative. Copper in 24 hour urine and seruloplasmine were normal. Liver biopsy showed lower interlobular cholestatic chanels and hepatocellular giant cell transformation. Phsycians should not delay for liver biopsy to diagnosis of interlobular paucity in adolescents with cholestatic signs if there is no primary disease for cholestasis.
NaturalLanguageKeyword :
Interlobular paucity , adolescent
JournalTitle :
Gulhane Medical Journal
