Çobankara, Veli Pamukkale Üniversitesi - Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Turkey , Balkarlı, Ayşe Pamukkale Üniversitesi - Tıp Fakültesi - İç Hastalıkları AD, Romatoloji BD, Turkey

Familial Mediterranean Fever

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Familial Mediterranean Fever (FMF) is the most common autoinfl amatory disorder. It is characterized by paroxysmal attacks of fever and serosal infl ammation. It is inherited as an autosomal recessive trait in short arm of 16th Chromosome (MEFV gene). FMF has been described primarily in several ethnic groups originating in the Mediterranean littoral suchas Sephardic Jews, Armenians, Turks, and Arabs. The typical manifestations of the disease are recurrent attacks of severe pain and fever, lasting one to three days, and then resolving spontaneously. In between attacks, patients feel entirely well. Pain and fever are usually abrupt and reach their peak soon after onset. Ninety-fi ve percent of patients with FMF have painful attacks localized in the abdomen, which is usually the dominant manifestation of the disease. Painful FMF attacks may also be localized in the chest. Arthritis is another common manifestation of FMF. Acute attacks of FMF are accompanied by elevation in many of the serum markers of systemic infl ammation. Colchicine is effective in most of the patients with FMF. In recent years, many developments occurred in genetic and treatment aspect of FMF. In this review, we try to mention these developments.

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Familial Mediterranean Fever , review , treatment , diagnosis

Pamukkale Medical Journal

98