Author/Authors :
Şevket, Osman Haseki Eğitim ve Araştırma Hastanesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Turkey , Ateş, Seda Haseki Eğitim ve Araştırma Hastanesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Turkey , Kılıç, Gökhan Haseki Eğitim ve Araştırma Hastanesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Turkey , Molla, Taner Haseki Eğitim ve Araştırma Hastanesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Turkey , Özkal, Fulya Haseki Eğitim ve Araştırma Hastanesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Turkey , Dansuk, Ramazan Haseki Eğitim ve Araştırma Hastanesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Turkey , Kelekçi, Sefa Dumlupınar Üniversitesi - Farmakoloji ve Klinik Farmakoloji Anabilim Dalı, Turkey
Abstract :
Purpose: To evaluate the utility of initial fasting plasma glucose (FPG) to limit the number of oral glucose tolerance test (OGTT)s needed for the diagnosis of gestational diabetes mellitus (GDM). Materials and methods: 390 pregnant women (estimated gestational ages 24–28 weeks) were evaluated for GDM using OGTT based on International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria. Two FPG thresholds (of the OGTT) were used to rule in and to rule out GDM. Results: Using IADPSG criteria, 61 (15.6%) of the participants had GDM. The area the under ROC curve of FPG used to detect GDM was 0.933. An FPG cut-off value of ≥5.1mmol/l had sensitivity of 70.49% and specificity of 100.00% in diagnosing GDM. An FPG cut-off value of ≤4.5 mmol/l had sensitivity of 93.44% and specificity of 67.6% in diagnosing GDM. Undergoing an initial FPG could have saved 67.7% of these women from taking the OGTT and only 1.5% (4 of the 264) would have been misclassified. Conclusion: Screening using an initial FPG rule-in and rule-out algorithm reduces the number of OGTTs needed for the diagnosis of GDM. Almost all GDM pregnancies can be diagnosed.
NaturalLanguageKeyword :
GDM , diagnosis , fasting plasma glucose , OGTT
