Semerci, C.Nur Pamukkale Üniversitesi Tıp Fakültesi - Tıbbi Genetik AD, Denizli , Alataş, Erkan Pamukkale Üniversitesi Tıp Fakültesi - Kadın Hastalıkları ve Doğum AD, Denizl , Sılan, Fatma Çanakkale Onsekiz Mart Üniversitesi - Tıp Fakültesi - Tıbbi Genetik AD, Çanakkale , Şatıroğlu-Tufan, N.Lale Ankara Üniversitesi Tıp Fakültesi - Adli Tıp AD ve Çocuk Genetik BD, Ankara , Dodurga, Yavuz Pamukkale Üniversitesi Tıp Fakültesi - Tıbbi Biyoloji AD, Denizli , Şatıroğlu, Hakan Özel HRS Kadın Hastanesi, Ankara.

Mutation analysis of HSFY gene by DNA sequencing in Turkish men with idiopathic infertility

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Purpose: In this study we planned to investigate HSFY gene mutations in Turkish infertile men with azoospermia, oligospermia and/or poor motility/morphology.Materials and methods: From three distinct medical centers, 41 Turkish infertile men contributed to this study. The patients included in the study had no endocrine or obstructive causes of spermatogenic failure and no Y microdeletion, and had normal karyotype. Mutation analysis of the HSFY gene was performed by DNA sequencing.Results: No variant could be detected in coding regions and flanking introns of HSFY gene in the study population.Conclusion: This study suggests no relation of HSFY sequence variant with spermatogenic failure and, the clinical molecular approach to diagnosis of individuals with spermatogenic failure is complicated due to extensive genetic heterogeneity and need more study to reveal causative genes and mutations of idiopathic infertility in men.

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Spermatogenesis , male infertility

Pamukkale Medical Journal

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4

2016