Yenilmez, Ebru Dündar Çukurova University - School of Medicine - Department of Medical Biochemistry, Turkey , Toyaksi, Hale State Hospital of Silifke - Department of Biochemistry, Turkey , Bozkurt, Abdi Çukurova University - School of Medicine - Department of Cardiology, Turkey , Tuli, Abdullah Çukurova University - School of Medicine - Department of Medical Biochemistry, Turkey , Acarturk, Esmeray Çukurova University - School of Medicine - Department of Cardiology, Turkey

Assessment of Diagnostic Efficiency of Lipoprotein (a), Homocysteine, High Sensitive C-Reactive Protein and Fibrinogen in Patients with Coronary Artery Disease

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Purpose: To evaluate the diagnostic value of major and other risk factors as lipoprotein (Lp) (a), homocysteine (Hcy), high sensitive C-reactive protein (hs-CRP) and fibrinogen in CAD patients. Materials and Methods: A total of 223 subjects (118 patients and 105 controls) were included in the study according to their coronary angiographic results. Lipoprotein (a), Hcy, hs-CRP and fibrinogen levels were measured using immunoturbidometric, florescent polarization immunoassay and nefelometric methods, respectively. Fasting glucose and lipid parameters, except low density lipoprotein cholesterol (LDL-C), are determined by enzymatic colorimetric methods and the LDL-C levels were calculated by the Fridewald formula.Results: Logistic regression analysis showed that when the biochemical variables in placed in a model, the most important variables were Lp (a), Hcy, hs-CRP and fibrinogen. We showed that each unit of Lp (a), Hcy, hs-CRP and fibrinogen increases the risk of CAD 1.029, 1.177, 1.027 and 1.013 fold, respectively. Among these, fibrinogen level was the most sensitive and efficient parameter in prediction of CAD.Conclusion: Although Lp (a), Hcy, hs-CRP and fibrinogen are independent risk factors for CAD, fibrinogen was the most important one. Fibrinogen can be used as a reliable risk factor for CAD in clinical practice.

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Coronary artery disease , risk factors , Lipoprotein (a) , Homocysteine , hs , CRP , fibrinogen

Cukurova Medical Journal

566