Author/Authors :
Kaplancıklı, Zafer Asım Anadolu University - Graduate School of Health Sciences, Turkey , Kaplancıklı, Zafer Asım Anadolu University - Graduate School of Pharmacy, Turkey , Altıntop, Mehlika Dilek Anadolu University - Graduate School of Pharmacy, Turkey , Turan-Zitouni, Gülhan Anadolu University - Faculty of Pharmacy, Turkey , Özdemir, Ahmet Anadolu University - Faculty of Pharmacy, Turkey , Demirel, Rasime Anadolu University - Faculty of Science, Turkey , Abu Mohsen, Usama Al-Azhar University - Faculty of Pharmacy, Palestine , Hussein, Weiam Anadolu University - Graduate School of Health Sciences, Turkey
Abstract :
Purpose: The objective of this study was to describe the synthesis of 2-arylthio-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide derivatives as heterocyclic compounds and focused on their potential antifungal effects against fungi species. Method: The reaction of 2-chloro-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide with various aromatic thiols gave 2-arylthio-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide derivatives. Antifungal activities of the synthesized compounds have been evaluated using microbroth dilution method. Results: Four new heterocyclic compounds were synthesized. All compounds were as effective as ketoconazole against T. harzianum, A. ochraceus, C. albicans, whilst the compounds were more effective than ketoconazole against F. solani, F. moniliforme, F. culmorum. Conclusion: All synthesized compounds had significant antifungal activity when compared with ketoconazole.
NaturalLanguageKeyword :
Antifungal activity , Microbroth dilution method , Dibenzofuran , Heterocyclic compound.
