Author/Authors :
Turan-Zitouni, Gülhan Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , Altintop, Mehlika Dilek Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , Özdemir, Ahmet Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , Demirci, Fatih Anadolu University - Faculty of Pharmacy - Department of Pharmacognosy, Turkey , Abu Mohsen, Usama Al-Azhar University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Palestine , Kaplancıklı, Zafer Asım Anadolu University - Faculty of Pharmacy, Graduate School of Health Sciences - Department of Pharmaceutical Chemistry, Turkey
Abstract :
Purpose: The synthesis of ten new naphthyridine-hydrazone derivatives and subsequent evaluation of their antimicrobial activities were aimed in this present work.Material and Methods: The structure of the compounds was elucidated by 1H-NMR and MS spectral data. Additionally the compounds were evaluated for their antimicrobial activity against a panel of pathogenic bacteria and fungus strains. The panel of microorganisms Escherichia coli, Salmonella typhimurium, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Listeria monocytogenes and Candida albicans were tested in vitro using a microdilution method.Results: All compounds showed significant antimicrobial activity against S. typhimurium and C. albicans when compared with reference agents.Conclusion: All synthesized compounds had significant antifungal activity when compared with ketoconazole.
NaturalLanguageKeyword :
Naphthyridine , Quinolone , Hydrazone , Antimicrobial Activity
