Author/Authors :
Taş, Didem Arslan Çukurova Üniversitesi - Tıp Fakültesi - Romatoloji-İmmünoloji Bilim Dalı, Turkey , Yüce, Ahmet Eftal Başkent Üniversitesi - Tıp Fakültesi - Romatoloji Bilim Dalı, Turkey , Özyılkan, Özgür Başkent Üniversitesi - Tıp Fakültesi - Medikal Onkoloji Bilim Dalı, Turkey
Abstract :
Sistemic sclerosis is a connective tissue disease which is characterized by the increase amount of collagene in subcutaneous tissue and internal organs. Several chemical agents and environmental factors are accused fort he etiopathogenesis however the etiology is not clear. There is limited data abput the increased frequency of colon carcinoma in the cases with sistemic sclerosis. There are 2 cases in the literature about the association between scleroderma and 5-fluorouracil which is used for the treatment of colon carcinoma. Similar clinical course and autoantibody positivity was also reported in a patient with tymic carcinoma who had been treated with 5-FU and folinic acid. In this article, a 51-year-old woman who developed scleroderma after 5-FU and folinic acid therapy which had been started for colon carcinoma has been reported.
