Kişi, Seda Mersin Kadın Hastalıkları ve Doğum Hastanesi - Anesteziyoloji Kliniği, Turkey , Güleç, Ersel Çukurova Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Türktan, Mediha Çukurova Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Hatipoğlu, Zehra Çukurova Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Güneş, Yasemin Çukurova Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey

The Effect of Gabapentin on Preoperative Anxiety and Postoperative Analgesia in Breast Cancer Surgery

23888

Purpose: The goal of this study was to evaluate the effect of pre-emptive gabapentin administration on anxiety and on postoperative tramadol requirement in patients undergoing breast cancer surgery.Material and Methods: After obtaining the local ethics committee approval and written informed consent, sixty-two patients with ASA physical status I-II aged 18-60 years and scheduled for breast cancer surgery were included into our study. They were randomly allocated into two groups. As control group did not receive premedication, the other group received 600 mg gabapentin per orally. We performed STAI-2 (The State-Trait Anxiety Inventory-2) and preoperatively STAI-1 (The State-Trait Anxiety Inventory-1) in both groups. Heart rate, systolic and diastolic blood pressure were recorded intraoperatively. 30 minutes before the end of surgery, 1mg.kg_-1 tramadol was administered intravenously for postoperative analgesia. Patient controlled analgesia device was used intravenously to provide postoperative analgesia. Postoperative VAS scores and postoperative tramadol requirement at 5, 10, 15, 30, 45th and 60th minutes and at 4, 8, 12, 24th hours were recorded.Results: Demographic data, hemodynamic values during the surgery, and anxiety scores were not different between two groups. Heart rate at 10th and 60th minutes intraoperatively, tramadol requirement and VAS scores postoperatively were significantly reduced in gabapentin group compared with control group (p 0.05) excluding VAS scores at the 5th, 10th minutes and .6th hours.Conclusion: We concluded that pre-emptive orally gabapentin reduced the total amount of tramadol consumption and provided effective analgesia and lower pain scores without hemodynamic side effect but did not affect the STAI-1 anxiety scores.

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Anxiety , Gabapentin , Patient controlled analgesia , Pre , emptive analgesia , Breast cancer

Cukurova Medical Journal

322