Author/Authors :
Topal, Ahmet Necmettin Erbakan Üniversitesi - Meram Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Sargın, Mehmet Konya Eğitim ve Araştırma Hastanesi - Anesteziyoloji ve Reanimasyon Kliniği, Turkey , Et, Tayfun Karaman Devlet Hastanesi, Turkey , Uzun, Sema Tuncer Necmettin Erbakan Üniversitesi - Meram Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey
Abstract :
Purpose: In diabetic patients, there may be obsserved functional loss of motor nerve fibers and this fact may affect the management of anesthesia in many ways.In our study we aimed to research if there is any differences between non-diabetic patients and the patients who have type 2 diabetes on the side of nueromuscular blockade characteristics of rocuronium.Material and Methods: 18 diabetic and 21 non-diabetic patients included to study, each patient evaluated by the NMT device after administiration of 0,6 mg/kg rocuronium intravenously.The onset of action time, clinical acting time , recovery time , total rocuronium dosage for each patient, amplitude of supramaximal excitation and Goldberg score were compared in the two groups.Results: Time of action (118,33±41,61 sn. 142,00±28,68 sn.) and recovery time (13,33±9,83 dak. 22,38±11,64 dak.) were longer than in diabetic patients (p 0,05), time of action and amplitude of supramaximal excitation were similar in two groups (p 0,05).Conclusion: We consider that the prolongation of onset of action time and recovery time in diabetic patients, is a complicaiton of diabetic neuropathy and diabetes may effect the pharmacodynamics of rocuronium.
NaturalLanguageKeyword :
Nneuromuscular block , rocuronium , diabetes , general anesthesia
