مرکز منطقه ای اطلاع رساني علوم و فناوري - Relationship between increased mean platelet volume and glycosylated hemoglobin (HbA1c) in type 2 diabetes mellitus

Abstract :

Purpose: The purpose of the study was to research relationship between mean platelet volume elevation and glycosylated hemoglobin A1c (HbA1c) in Type 2 diabetes mellitus (DM). Material and Methods: The study carried out in 70 patients with type 2 DM and 50 non-diabetic subjects. Diabetic patients were divided into two groups according to their HbA1c levels: DM group1 consisted of patients with HbA1c levels 7% and DM group 2 consisted of patients with HbA1c levels ≥7%. Results: The mean HbA1c levels were as 5.5±0.8, 6.7±0.2 and 9.7±1.9 in the non-diabetic, DM Group 1 and DM Group 2, respectively. MPV was significantly higher in DM Group2 as compared to both non-diabetics and DM Group 1. MPV had a high positive Correlation with HbA1c. MPV was significantly higher in DM Group 2 as compared to both non-diabetics and DM Group 1. MPV had a high positive correlation with HbA1c. It is found that MPV was increased in type 2 DM. Conclusion: This study showed that in diabetes mellitus, MPV is increased and it is indicative of worsening glycemic control. The increased platelet size may be one of the factors in the increased risk of atherosclerosis associated with DM and associated micro and macro vascular complications.