SEREFHANOĞLU, Songül Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , BÜYÜKASIK, Yahya Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , AKSU, Salih Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , GÖKER, Hakan Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , SAYINALP, Nilgün Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , ÇETiNER, Deniz Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , HAZNEDAROĞLU, ibrahim Celalettin Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, Turkey , ÖZCEBE, Osman ilhami Hacettepe Üniversitesi - Hacettepe Tıp Fakültesi - iç Hastalıkları Anabilim Dalı, turkey

THE FACTORS INFLUENCING OVERALL SURVIVAL IN NEWLY DIAGNOSED ADULT ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS

25899

Objective: The prognosis of patients with acute lymphoblastic leukemia (ALL), treated with modern chemotherapeutic regimens, is dependent on a number of variables. Determination of these factors is crucial for adapting post remission therapy in adult ALL. We herein, stutried to explore the clinical characteristics of adult ALL and analyze the prognostic factors. Materials and methods: Data of 65 newly diagnosed adult ALL patients hospitalized in our institute between January 2003 and December 2008 were retrospectively reviewed. Median age was 35, 6 (range 16-74) and, 70% had B-lineage ALL, 20% had T-lineage ALL and 10% had Burkitt ALL. Thirty-two patients received Hyper-CVAD, 25 received CALGB-881, 3 received HAM (High dose ARA-C and Mithoxantrone), one received MOPP, one received St Jude Total XIII and one received CHOP-21. One patient had complete remission with CLAGB-881 but due to liver toxicity was maintained with Hyper-CVAD regimen. One patient died before treatment.Results: The mean follow-up time was 407 (0-1706) days. Cytogenetic analysis was performed in all patients, 9 cases of them had t(9;22), 2 had t(4;11) and one had myc-oncogen. The response rates in patients after the induction regimens; 60% (n=39) achieved complete remission (CR), 32% (N=21) died during induction (induction mortality) and 8% (n=5) had resistant disease. The OS rate at 4, 6 years was 19%. DFS rate at 4, 5 years was 28%.Conclusion: In univariate analysis, immunophenotype (Burkitt, B- or T-ALL), ECOG performance status (≤1 or 1) and age (≤ 30 or other) found that related to overall survival. In multivariate analysis, age (p=0.018) and ECOG performance status (p=0.010) found that associated with overall survival

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Adult acute lymphoblastic leukemia , overall survival , disease , free survival

Journal Of Istanbul Faculty Of Medicine

12