TEKKEŞİN, Merva Soluk İstanbul Üniversitesi - Onkoloji Enstitüsü - Tümör Patolojisi Bilim Dalı, Turkey , ERSAN, Nilüfer Yeditepe Üniversitesi - Diş Hekimliği Fakültesi - Ağız-Diş ve Çene Radyolojisi Anabilim Dalı, Turkey , AKSAKALLI, Nihan İstanbul Üniversitesi - Onkoloji Enstitüsü - Tümör Patolojisi Bilim Dalı, Turkey , OLGAÇ, Vakur İstanbul Üniversitesi - Onkoloji Enstitüsü - Tümör Patolojisi Bilim Dalı, Turkey , ALATLI, Canan İstanbul Üniversitesi - Onkoloji Enstitüsü - Onkolojik Sitoloji Bilim Dalı, Turkey

ORAL SQUAMOUS CELL CARCINOMA: RETROSPECTIVE STUDY OF 147 CASES

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Objective: Squamous epithelium is the primary surface structure of the skin, lips, and mucous membranes of the oral cavity and 86 % to 95 % of head and neck malignancies originate from this surface epithelium. Oral squamous cell carcinoma (OSCC) accounts for more than 90 % of malignant tumours of the oral cavity. It is most likely to appear in males over 40 years of age. Smoking, alcohol consumption and poor oral hygiene are identified as the most common etiological factors. The first sign is asymptomatic ulcerations clinically. The most frequent anatomical site is tongue, followed by mouth floor, alveolar ridge, and hard palate. The aim of the study is to evaluate the clinical and histopathological features of OSCC and to arise awareness while presenting how often the dentists come cross OSCC. Material and Method: A retrospective study was carried out on records of 147 patients diagnosed as OSCC between 1999 and 2010 at the Department of Tumour Pathology in Istanbul University, Institute of Oncology. In the content of this evaluations patient records were compared according to age and sex of the patient, tumour localization, institution referring the sample, and clinical diagnosis. Hematoxylin-eozin stained slides were evaluated according to differentiation grades. All graphics and evaluation were performed by Microsoft Office Excel 2007. Results: Among 147 patients, 50 (34.01 %) were female whilst 97 (65.98 %) were male.Mean age was found as 60.51. Of these biopsies, 116 (78.91 %) were referred from university hospitals and 96 (82.75 %) of these were from dental faculties. The most frequent localization was alveolar ridge with 91 (61.90 %) patients. Histopathologically 43.53 % of the cases were well differentiated, 28.57 % were moderately differentiated, and 19.72 % were poorly differentiated OSCC. Conclusion: Early diagnosis is essential to cure in oral squamous cell carcinoma as well as other cancer types. Treatment and disease-free survival rates are directly related to the size of the tumour. Most of the early stage OSCC patients are first seen by dentists who play a critical role in prevention of oral cancer. Therefore, while dentists perform routine oral examination on middle aged and elder patients it is vital importance to pay more attention on ulcerative/erosive lesions.

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Oral squamous cell carcinoma , epidemiology , oral cancers

Acta Odontologica Turcica

98