Author/Authors
Ulusoy, Canan Aysel Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Sinirbilim Anabilim Dali, Turkey , Turan, Selin Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Sinirbilim Anabilim Dali, Turkey , Tüzün, Erdem Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Sinirbilim Anabilim Dalı, Turkey
Title Of Article
Prevalence Of Glutamic Acid Decarboxylase Antibody In Autoimmune Encephalitis And Its Clinical Spectrum
شماره ركورد
26276
Abstract
High prevalence of autoantibodies against glutamic acid decarboxylase (GAD-Ab) in autoimmune encephalitis patients both helps diagnosis and suggests immune mediated pathogenesis in autoimmune syndromes. Serum GAD-antibodies were investigated with ELISA in 140 patients with suspected autoimmune encephalitis and found positive in 10 patients (%17.5) with stiff-man syndrome, cerebellar degeneration, limbic encephalitis and epilepsy. Raised GAD-Ab positivity clustered in a subgroup with limbic encephalitis or isolated seizures. A single patient with lung cancer also displayed GAD-Ab. Overall, GAD-Ab positive patients showed partial to full response to immunotherapy. In autoimmune encephalitis patients, GAD-Ab may be used as a biomarker for cancer screening indication and good response to immunotherapy.
From Page
23
JournalTitle
Deneysel Tıp Araştırma Enstitüsü Dergisidir
To Page
27
JournalTitle
Deneysel Tıp Araştırma Enstitüsü Dergisidir
Link To Document