Author/Authors :
yanar, fatih istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , coşkunpınar, ender istanbul sağlık bilimleri üniversitesi - tıp fakültesi - tıbbi biyoloji ana bilim dalı, Turkey , tokat, bengu istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , buğra, zehra istanbul üniversitesi - istanbul tıp fakültesi - iç hastalıkları anabilim dalı, kardiyoloji bilim dalı, Turkey , öztürk, oğuz istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , yılmaz-aydoğan, hülya istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey
Abstract :
Objective. Atherosclerosis which has a role in etiopathology of coronary artery disease (CAD) is a process that occurs in time when the arteries lost their flexibility. It was known that the regulation of energy and the melanocortin pathway which has a special role in appetite is effective in development of obesity. Studies in recent years show that in rats the central injection of nesfatin-1 which is a new identified gene in this pathway reduces food intake. It was showed that the nesfatin-1 has an appetite suppressant effect and it has a role in central pathways that control food intake. Because of NUCB2/Nesfatin-1 has an effect on obesity it is a candidate gene which is responsible for causing CAD. In our thesis project we intend to identify the relationship between NUCB2 gene variations and the atherosclerotic risk factors like obesity, type2 diabetes mellitus, gender and the progress risk of CAD that is occuring as a result of atherosclerosis. Material and Methods. Our study groups consisted of 65 CAD patients and 39 healthy controls and rs1330, and rs757081 variations are investigated. Genotypes were determined by realtime PCR. Results. Genotype and allele frequencies of rs757081 ve rs1330 are similar in CAD and in control group (p 0.05). In CAD group of rs1330 normal CC genotype has higher leves of LDL-C (p= 0,043) and SBP(p=0,035) in comparison with CT genotype. And also in CAD group total the risk of having cholesterol ≥5,18 is observed high levels in rs1330 C allele. Conclusion. Our findings indicate that the NUCB2/Nesfatin-1 gene variations may be associated with metabolic risk factors in coronary artery disease.
