Author/Authors :
Vrabie, Camelia Doina National Institute of Pathology “Victor Babes”, Romania , Vrabie, Camelia Doina Clinical Hospital of Emergency “Sfantul Ioan”, Romania , Vrabie, Camelia Doina University of Medicine “Carol Davila”, Romania , Cojocaru, Manole University of Medicine Titu Maiorescu, Romania , Waller, Maria National Institute of Pathology “Victor Babes”, Romania , Sindelaru, Ruxandra University of Bucharest Romania, Romania , Copaescu, Catalin Clinical Hospital of Emergency “Sfantul Ioan”, Romania
Abstract :
Objectives: The prevalence of obesity has been increasing in recent decades in developed countries. Slight and moderate obesity is associated with various co-morbidities. The most severe forms of obesity are consistently associated with the development of various health problems. The aim of this study was to investigate and analyze the most important histopathological lesions obtained by sleeve gastrectomy postoperatively. Materials and methods: We investigated 87 surgical interventions, performed between October of 2007 and June of 2008 for bariatric therapy procedures, using sleeve gastrectomy. All the specimens (gastric, liver and adipose tissue) were processed in the Pathology Department. The specimens were fixed in buffered formalin, and then stained with hematoxilin eosin. Results: The female to male ratio was 2/1. Young patients aged between 31-40 years were most frequently (39.1%) affected. The frequent histopathological lesions were parietal cells hyperplasia (63.2%), ulcerations (34.5%), lymph nodes hyperplasia in lamina propria (33.3%), active gastritis (23.0%) and other lesions (10.3%). The parietal cells hyperplasia found in fornix and corpus mucosa was the most frequent lesion encountered in obese patients. All three cases showed an important steatosis of the hepatocytes by liver biopsy. Conclusions: Our results suggest that the histopathology analysis of the gastric mucosa of the fornix and other tissues (as the liver) is relevant for the comorbidities of the obese patients. The evaluation of the histopathological gastric and liver aspects could improve the understanding of the local mechanism and the outcome of the patients.
NaturalLanguageKeyword :
Morbid obesity , sleeve gastrectomy , histopathology , lesions
