Author/Authors :
Çevik, Figen Ceylan Dicle Üniversitesi - Tıp Fakültesi - Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Turkey , Yazıcı, Selma Dicle Üniversitesi - Tıp Fakültesi - Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Turkey , Tahtasız, Mehmet Dicle Üniversitesi - Tıp Fakültesi - Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Turkey , Kara, Ali Fuad Dicle Üniversitesi - Tıp Fakültesi - Kardiyoloji Anabilim Dalı, Turkey , Çil, Habib Dicle Üniversitesi - Tıp Fakültesi - Kardiyoloji Anabilim Dalı, Turkey , Atılgan, Zuhal Dicle Üniversitesi - Tıp Fakültesi - Kardiyoloji Anabilim Dalı, Turkey , Tekbas, Ebru Dicle Üniversitesi - Tıp Fakültesi - Kardiyoloji Anabilim Dalı, Turkey , Saraç, A. Jale Dicle Üniversitesi - Tıp Fakültesi - Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Turkey
Abstract :
Objective: Cardiac involvement occurs due to the disease itself and secondary to the used drugs, and commonly develops silent in rheumatoid arthritis (RA). In this study, it was investigated the presence of cardiac involvement by non-invasive electrophysiological parameters Materials and Methods: 49 patients with RA and agematched 28 healthy subjects as control group were enrolled to this study. Clinical and laboratory parameters of all subjects were assessed and 24-hour electrocardiographic Holter monitoring were performed. Results: Minimum, maximum and mean heart rate were signifi cantly higher (p 0.05, p 0.01, p 0.01, respectively), while maximum QT interval were signifi cantly lower in patients with RA compared to controls (p 0.05). P wave parameters (P maximum, P minimum and P dispersion) were similar both groups. In correlation analysis, there was only signifi cant negative association between erythrocyte sedimentation rate and corrected QT dispersion (r=0.317, p 0.05). However, it was not found any association between P wave and QT parameters and other anyone of clinical or laboratory parameters. Conclusion: There is modest role of non-invasive parameters such as QT dispersion in assessment of cardiovascular risk and prediction of sudden cardiac dead risk in addition to the traditional risk factors in patients with RA. However, prospective, larger and long term studies which include different patient groups are needed to obtain more accurate conclusions.
NaturalLanguageKeyword :
Rheumatoid arthritis , Holter electrocardiography , QT dispersion , heart rate variability.
