Evaluation of role of Low Molecular Weight Heparin and Vitamin E on renal functions in patients with diabetic nephropathy

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Objectives: Diabetes has been reported to increase the risk of end stage renal disease. To prevent the progression of diabetic nephropathy (DN) search for newer approaches is warranted as diabetic patients despite good metabolic control show progressive renal damage. The aim of this study was to investigate the role of low molecular heparin (LWMH) and vitamin E in patients with diabetic nephropathy.Materials and methods: Twenty five clinically proved adult cases of DN with adequate glycemic and blood pressure control achieved with insulin or oral hypoglycemics and anti hypertensive agents (excluding ACE inhibitors and ARBs) were included. At the start of the study, patients were put on LWMH (3200 IU S/C once daily) for one month and thereafter a washout period of one month was given, following which patients received anti-oxidant vitamin-E (200mg, once daily) for three months.Results: Patients at the baseline have microalbuminuria levels ranging for 41.0 to 290.0 mg/ 24hr. One month of LMWH reduced it from 133.0±74.4 to 93.3±62.1 mg/24hr (p 0.001). Vitamin E supplementation for 3 months did not bring any statistically significant change in the values of microalbuminuria which varied from 95.2±13.0 to 94.2±12.9 mg/24hr (p 0.05). The microalbuminuria levels did not revert back to the baseline till the end of the study (5 months).Conclusion: Our results indicated that, though not a part of standard regime, LMWH treatment followed by vitamin E supplementation needs to be considered in the incipient stage of DN.

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Low molecular weight heparin , vitamin E , diabetic nephropathy , renal functions

Dicle Medical Journal

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Dicle Medical Journal