Özer, Türkan Toka Kızıltepe General Hospital - Department of Medical Microbiology, Turkey , Yula, Erkan Mustafa Kemal University - Medical Faculty - Department of Medical Microbiology, Turkey , Tekin, Alicem Dicle University - Medical Faculty - Department of Medical Microbiology, Turkey , Deveci, Özcan Dicle University - Medical Faculty - Department of Infectious Diseases, Turkey

Fusidic acid resistance among staphylococci strains isolated from clinical specimens in a general hospital

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Objectives: The aim of this study was to investigate in vitro susceptibility of fusidic acid to clinic isolates of staphylococci. Materials and methods: The forty-one coagulase negative staphylococci (CNS) and 18 Staphylococcus aureus strains isolated from various clinical specimens were included in this study. Staphylococci isolates were identified by conventional methods such as colony morphology onto medium, gram staining, catalase and coagulase tests. According to “Clinical and Laboratory Standards Institute (CLSI)” criteria, antimicrobial susceptibility testing of isolates was performed by Kirby-Bauer’s disk diffusion method. Results: The seventy-two percent of the isolated S.aureus were defined as methicillin sensitive-S.aureus (MSSA), 28% of the isolated S.aureus were defined as methicillin resistant-S.aureus (MRSA). The difference among fusidic acid susceptibility rates of MSSA and MRSA strains was not statistically significant (p=0.305). The twenty-nine percent of the isolated CNS were defined as methicillin sensitive-CNS (MS-CNS), 71% of the isolated CNS were defined as methicillin resistant-CNS (MR-CNS). There was no statistically significant difference between MS-CNS and MR-CNS strains for fusidic acid susceptibility rates (p=0.490). But the difference among fusidic acid susceptibility rates of CNS and S.aureus strains was statistically significant (p 0.001). CNS strains were found more resistance than S.aureus strains for fusidic acid. Conclusion: In this study, the resistance rates were detected to increase for fusidic acid along with methicillin resistance. Among CNS isolates, fusidic acid resistance rates were significantly more elevated than that for S.aureus. Fusidic acid remains as an alternative in the treatment of infections due to staphylococci.

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Staphylococcus aureus , fusidic acid , microbial sensitivity test

Dicle Medical Journal

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