Uçmak, Derya Dicle University - Faculty of Medicine - Department of Dermatology, Turkey , Balcı, Gökçen Dicle University - Faculty of Medicine - Department of Dermatology, Turkey , Harman, Mehmet Dicle University - Faculty of Medicine - Department of Dermatology, Turkey

Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus

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Objectives: Lichen planus is an immunologic disease mediated by lymphocytes in which T lymphocytes target at basal cells. It is believed that TNF-α that is released from T lymphocytes and keratinocytes plays a key role in the starting and progression of lichen planus by inducing apoptosis. MHC Class-I antigens on basal keratinocytes and interleukin-2 (IL-2) and IFN-gamma (γ) that are pro-duced from CD4+ T cells stimulate the apoptosis of keratinocytes in lichen planus. The aim of this study was to measured the IL-2 and TNF-α levels in peripheral blood from patients with Lichen planus. Materials and methods: A total of 26 lichen planus patients (18 females, 8 males) that applied to the dermatology policlinics in Dicle University Hosspital between 2004 and 2006 and a healthy control group were included in the study. Serum IL-2 and TNF-α levels were measured by using Immulate 1000 solid phase and two-site chemiluminescent immunometric assay method. The results of patients and control group were compared. Results: Level of IL-2 (1172.615 ± 774.967) and TNF-α (13.361 ± 5.638) were higher in lichen planus to compared controls. IL-2 and TNF-α levels in the patient group were found to be significantly high statistically compared to health control group, respectively p=0.004 and p 0.001. Conclusion: The high levels of IL-2 and TNF-α in lichen planus patients support the role of immunity in the pathogenesis of the disease.

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Lichen planus , IL , 2 , TNF , α

Dicle Medical Journal

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