Author/Authors :
Çevik, Mehmet Uğur Dicle Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Varol, Sefer Dicle Üniversitesi - Tıp Fakültesi - Hastanesi Nöroloji Anabilim Dalı, Türkiye , Yücel, Yavuz Dicle Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Akıl, Eşref Dicle Üniversitesi - Tıp Fakültesi - Hastanesi Aile Hekimliği Anabilim Dalı, Türkiye , Çelepkolu, Tahsin Dicle Üniversitesi - Tıp Fakültesi - Hastanesi Nöroloji Anabilim Dalı, Türkiye , Arıkanoğlu, Adalet Dicle Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Yüksel, Hatice Dicle Üniversitesi - Tıp Fakültesi - Hastanesi Biyokimya Anabilim Dalı, Türkiye , Aluçlu, Mehmet Ufuk Dicle Üniversitesi - Tıp Fakültesi - Hastanesi Nöroloji Anabilim Dalı, Türkiye
Abstract :
Objectives: We aimed to evaluate antioxidant paraoxonase-1 (PON-1) activity together with malondialdehyde (MDA) (an oxidative stress parameter) levels in patients with epilepsy. Materials and methods: Forty-five epilepsy patients were included in the study and compared with healthy controls (n = 45). The levels of serum MDA and PON-1 activities were measured by the Ohkawa method and the Eckerson method, respectively. Results: Serum MDA level was significantly higher (P = 0.015), whereas PON-1 activity was sigificantly lower (P = 0.011) in the patient group than the controls. Conclusions: Increased reactive oxygen species levels in epilepsy may result in a oxidative stress, which in turn could result in decreased antioxidant PON-1 activity and increased MDA levels.
NaturalLanguageKeyword :
Epilepsy , oxidative stress , malondialdehyde , paraoxonase , 1
