Author/Authors :
Yamak, Nesibe Düzce Üniversitesi - Sağlık Bilimleri Enstitüsü - Tıbbi Biyoloji ve Genetik Anabilim Dalı, Türkiye , Yaykaşlı, Kürşat Oğuz Düzce Üniversitesi - Tıp Fakültesi - Tıbbi Genetik Anabilim Dalı, Türkiye , Soğuktaş, Hatice Düzce Üniversitesi - Sağlık Bilimleri Enstitüsü - Tıbbi Biyoloji ve Genetik Anabilim Dalı, Türkiye , Yaykaşlı, Emine Düzce Üniversitesi - Sağlık Bilimleri Enstitüsü - Tıbbi Biyoloji ve Genetik Anabilim Dalı, Türkiye , Oktay, Murat Düzce Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye , Erdem, Havva Düzce Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye , Kaya, Ertuğrul Düzce Üniversitesi - Tıp Fakültesi - Tıbbi Farmakoloji Anabilim Dalı, Turkey , Ekinci, Aysun Diyarbakır Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Türkiye , Kaya, Savaş Dicle Üniversitesi - Tıp Fakültesi - İmmünoloji Anabilim Dalı, Türkiye , Kurman, Yener Düzce Üniversitesi - Sağlık Bilimleri Enstitüsü - Tıbbi Biyoloji ve Genetik Anabilim Dalı, Türkiye
Abstract :
Objectives: Despite decreasing incidence of gastric cancer in worldwide, it is still a major health problem. Every year, 30.000 new gastric cancer cases emerging, and it is the second most common cancer in Turkey. Gastric cancer is a complex multifactorial disease, emerging by interaction between genetic and environmental factors. Survivin, apoptosis inhibitory protein is over-expressed in cancer tissue. In this study, association between Survivin -31G/C polymorphism and gastric carcinoma was investigated. Materials and Methods: 46 gastric carcinoma patients who had been admitted at Düzce University Research and Practice Hospital, Laboratory of Pathology and 42 healthy individuals have been included in the study. Samples have been subjected to genetic analysis by PCR-RFLP method in Medical Genetics Department laboratory at Düzce University. Results: GG genotype was found in 16 (34.8%), GC genotype in 21 (45.7%), CC genotype in 9 (19.6%) in patient group. In control group, genotype distribution were found 13 (31%), 26 (61.9%) and 3 (7.1%) respectively. The statistically significant difference was not found when compared between patient and control groups. However, we observed the increased occurrence of gastric cancer associated with CC genotype (OR=1.52). Conclusions: In our knowledge, this study is the first to evaluate the relationship between gastric carcinoma and Survivin -31G/C polymorphism in Turkish population. Our results show that there is no any association between gastric carcinoma and Survivin -31G/C polymorphism in the community which is represented by our study and control groups. However, it was concluded that CC genotype may create the susceptibility to gastric cancer.
NaturalLanguageKeyword :
Polymorphism , gastric carcinoma , surviving gene , apoptosis
