Süner, Ali Gaziantep Üniversitesi - Tıp Fakültesi - Gaziantep Onkoloji Hastanesi, Tıbbi Onkoloji Anabilim Dalı, Türkiye , Tutar, Ediz Gaziantep Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye , Kalender, Mehmet Emin Gaziantep Üniversitesi - Tıp Fakültesi - Gaziantep Onkoloji Hastanesi, Tıbbi Onkoloji Anabilim Dalı, Türkiye , Kazancı, Ülkü Gaziantep Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye , Arslan, Sibel Karahan Gaziantep Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye , Balakan, Ozan Gaziantep Üniversitesi - Tıp Fakültesi - Gaziantep Onkoloji Hastanesi, Tıbbi Onkoloji Anabilim Dalı, Türkiye , Karataş, Erkan Gaziantep Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye , Kanlıkama, Muzaffer Gaziantep Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Türkiye

The relationship between prognostic parameters and tumor associated tissue eosinophilia in supraglottic laryngeal tumors

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Objective: Tumor-associated tissue eosinophilia (TATE) has been noted in human cancers, sometimes with different results regarding their association with clinical outcome. In this study, the association between TATE and prognostic parameters of supraglottic laryngeal cancer was analyzed. Materials and methods: Sixty-two patients with diagnosis of supraglottic laryngeal squamous cell carcinoma and who treated surgically in our center were evaluated. The cases were divided into 3 categories according to the average number of eosinophils per high-power field (400x): 0 (negative), 1-5 (grade 1+), more than 5 (grade 2+). Results: We found 24 TATE-negative (38.7%) and 38 TATE-positive (61.3%) cases. There was not any statistically significant correlation between TATE and tumor differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients’ ages, T stages (p 0.05). As expected, vascular invasion correlated with lymph node metastasis (p=0.001). Conclusion: The results of this study showed that TATE has no correlation with prognostic parameters such as histologic differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients’ ages and T stages in supraglottic laryngeal squamous cell carcinoma. The data suggest that stromal eosinophilic infiltration is not useful for determining biological aggressiveness in supraglottic laryngeal cancer.

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laryngeal carcinoma , supraglottic , eosinophilia , prognostic parameters

Dicle Medical Journal

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