Çatak, Onur Elazığ Eğitim ve Araştırma Hastanesi - Göz Hastalıkları Bölümü, Türkiye , Çeliker, Ülkü Fırat Üniversitesi - Tıp Fakültesi - Göz Hastalıkları Anabilim Dalı, TÜRKİYE

The effect of topical cyclosporine A on tear film instability in patients with posterior blepharitis

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Objective: The aim of this study is to evaluate the efficacy of topical cyclosporine A (CsA) 0.05% (Restasis, Allergan Pharmaceuticals) in patients with posterior blepharitis. Methods: The study included 15 patients with posterior blepharitis. Topical CsA 0.05% (Restasis, Allergan Pharmaceuticals) was applied twice a daily for 2 months. They were evaluated at baseline and after treatment for subjective symptoms and objective signs including tear breakup time (BUT), Schirmer scores, conjunctival hyperemia, tarsal telangiectasis and Meibomian gland inclusions. Results: Fifteen patients completed the study. At the 2-month visit, the patients showed improvement in ocular symptom including burning, itching, conjunctival hyperemia (p 0.05; p 0.001; p 0.001, respectively). Topical administration of CsA provided improvement in Schirmer scores (p 0.001) Conclusion: Topical CsA was inducing an improvement in the ocular symptoms. Topical CsA 0.05% may be helpful in the treatment of posterior blepharitis. These findings should be further evaluated in large-scale.

446

Posterior blepharitis , Cyclosporine A , Schirmer scores , breakup time

Dicle Medical Journal

448