Torun, Emel Bezmialem Vakıf University - Medical Faculty - Department of Pediatrics, Turkey , Tanyeri, Bilge Bezmialem Foundation Universityof Medicine - Department of Pediatrics, Division of Neonatology, Turkey , Ünsal, Nursel Bezmialem Vakıf Üniversitesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Turkey , Demir, Ayşegül Doğan Bezmialem Vakıf Üniversitesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Turkey , Bayraktar, Süleyman Bezmialem Vakıf Üniversitesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Turkey , Öktem, Faruk Bezmiâlem Vakıf Üniversitesi - Tıp Fakültesi - Çocuk Nefroloji Bilim Dalı, Turkey

The effect of phototherapy on oxidative stress in newborns with indirect hyperbilirubinemia

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Objective: Phototherapy, used for indirect hyperbilirubinemia therapy in newborn period, is supposed to cause oxidative damage by enhancing the photodynamic stress and lipid peroxidation. Therefore, we aimed to compare the oxidant and antioxidant status of hyperbilirubinemic newborns before and after the phototherapy. Methods: Twenty-nine newborns (16 male, 13 female) exposed to phototherapy with the diagnosis of indirect hyperbilirubinemia were included in the study. The serum total antioxidant capacity, total oxidative stress and oxidative stress index levels were measured before and after the phototherapy. Results: The newborn infants were 38.5±0.7 (38-40) weeks of gestation and had birth weight of 3108.2±341.6 (2500-3800) grams. The mean mother age was 26.5±5 (16-36) years. The mean hospitalization duration was 4.4± 1.9 (2-7) days and the mean phototherapy duration was 1.52±0.6 (1-3) days. There was no statistically significant relation between gestation week, birth weight and total antioxidant levels (p 0.05) but the oxidative stress levels was significantly higher with longer hospitalization (p=0.047). Both total antioxidant capacity and total oxidative stress levels were low and statistically insignificant (P 0.001) and there was no significant difference for oxidative stress index levels. Conclusion: Phototherapy did not increase the oxidative stress in the newborns with indirect hyperbilirubinemia and this can be explained by the rapid decrease of indirect hyperbilirubinemia after the phototherapy without sufficient increase of the antioxidants.

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Newborn , jaundice , phototherapy , total antioxidant capacity , total oxidative stress , oxidative stress index

Dicle Medical Journal

383