Koçarslan, Aydemir Harran University - Faculty of Medicine - Department of Cardiovascular Surgery, TURKEY , Hazar, Abdüssemet Harran Üniversitesi - Tıp Fakültesi - Kalp Damar Cerrahisi Ana Bilim Dalı, Türkiye , Aydın, Mehmet Salih Harran Üniversitesi - Tıp Fakültesi - Kalp ve Damar Cerrahisi Anabilim Dalı, Turkey , Aksoy, Nurten Harran University - Faculty of Medicine - Department Clinical Biochemistry, TURKEY , Göz, Mustafa Harran University - Faculty of Medicine - Department of Cardiovascular Surgery, TURKEY

The impact of preoperative trimetazidine use on oxidative parameters in patients undergoing coronary bypass surgery

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Objective: This prospective, randomised, controlled, clinical study was planned to determine the effect of trimetazidine on myocardial ischemia-reperfusion during on pomp coronary artery bypass graft surgery (CABG). Methods: Thirty-five patients undergoing elective CABS in our hospital between 2008 and 2009 were included. The patients were divided into two groups randomly. Seventeen patients consisted trimetazidine group and preoperative trimetazidine PO received for two weeks, whereas 18 cases were controls. Venous blood samples were drawn, preoperatively, intraoperatively and postoperatively, whereas coronary sinus blood samples were drawn before and after cardiopulmonary bypass. At the end, total oxidative status (TOS) and total antioxidant status (TAS) were studied and oxidative stress index (OSİ) was calculated. Repeated measures analysis of variance was used to test the influence of operative stress and trimetazidine use on oxidative parameters. Results: Trimetazidine had no impact on total oxidative status, total antioxidant status and oxidative stress index (p 0.05). However, repeated measurements of total oxidative status, total antioxidant status and oxidative stress index have revealed significant impact of operative stress on oxidative parameters (p 0.05). Conclusion: Preoperative trimetazidine use had no impact on total oxidative status, total antioxidant status and oxidative stress index contrary to significant influence of operative stress on oxidative parameters.

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Coronary bypass surgery , trimetazidine , oxidative stress

Dicle Medical Journal

596