Author/Authors :
Alataş, Emine Tuğba Elazığ Eğitim ve Araştırma Hastanesi Dermatoloji Servisi, Türkiye , Kökçam, İbrahim Fırat Üniversitesi - Tıp Fakültesi - Deri ve Zührevi Hastalıkları Anabilim Dalı, Turkey
Abstract :
Objective: Psoriasis is a chronic, T-cell mediated inflammatory skin disease with multifactorial etiology. Adiponectin, leptin and apelin are the adipokines that aresecreted from adipose tissue and plays a role in T-cell immunity. In this study, it wasaimed to investigate potential relationship between adiponectin, leptin, apelin and psoriasis. Methods: Fasting plasma glucose, triglyceride, HDL cholesterol and serum adiponectin, leptin and apelin levels were measured in 50 adult patient with psoriasis, 20 patients with pemphigus vulgaris and 46 healthy individuals. In addition, BMI, waist circumference and blood pressure were measured in patient and control groups. Results: Metabolic syndrome frequency was found as significantly higher in patients with psoriasis than control group (p 0.05). It was found that serum adiponectin levels were significantly lower in patients with psoriasis than those in control group, while leptin and apelin levels were significantly higher (p=0.004, p=0.018 and p=0.003, respectively). Serum leptin levels were found as significantly higher in patients with pemphigus vulgaris than those in healthy controls (p=0.019). No significant difference was found between psoriasis patients with metabolic syndrome and without metabolic syndrome serum adiponectin, leptin and apelin levels (p 0.05, p 0.05 and p 0.05, respectively). No significant difference was found between PASI score and adiponectin, leptin, apelin values. Conclusion: In our study demonstrates the frequency of metabolic syndrome in patients with psoriasis. We think that adiponectin, leptin and apelin may play role in the pathogenesis of psoriasis, but these adipokines aren’t markers, which are related to severity of disease.
NaturalLanguageKeyword :
Psoriasis , metabolic syndrome , adiponectin , leptin , apelin
