Çavdaroğlu, Banu Özel Sarıyer Tıp Merkezi - Biyokimya Laboratuvarı, Turkey , Köse, Nurgül Metin Sabancı Baltalimanı Kemik Hastalıkları Eğitim Araştırma Hastanesi - Fizik Tedavi Kliniği, Türkiye , Başkol, Gülden Erciyes Üniversitesi - Tıp Fakültesi - Biyokimya Anabilim dalı, Turkey , Demir, Hüseyin Erciyes Üniversitesi - Tıp Fakültesi - Fizik Tedavi ve Rehabilitasyon Anabilim dalı, Turkey

Evaluation of protein and lipid oxidative stress in the patients with postmenopausal osteoporosis

26967

Objective: Oxidative stress may change cellular function in multiple pathological conditions, including osteoporosis. We aimed to determine malondialdehyde (MDA) levels, advanced oxidation protein pruducts (AOPP), levels end products of protein oxidation, thiol as known antioxidant, serum paraoxonase 1 (PON1) activities as known lipid antioxidant, induced by reactive oxygen species (ROS) for evaluating oxidative stress in osteoporotic patients. Methods: 59 patients diagnosed with postmenopaual osteoporosis were included in the study and compared with 21 healthy controls. Serum AOPP, MDA, thiol levels and PON1 activity were measured according to an enzymatic spectrophotometric method. Results: The serum MDA, AOPP, and thiol levels was significantly higher in the patient group than controls (p 0.05). PON1 activity was found lower in the patients group than the control group. Conclusion: Increased ROS levels in osteoporotic patients may result in a pro-oxidation environment, which in turn could result in increased MDA, AOPP. As a result, lipid peroxidation and protein oxidation may have a role in the pathogenesis of the osteoporotic patients.

71

Lipid peroxidation , protein oxidation , osteoporosis , oxidative stress

Dicle Medical Journal

77