Author/Authors :
Uzun, Fatih Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Bıyık, İsmail Usak State Hospital - Department of Cardiology, Turkey , Ameri, Mohammad Toib Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Erturk, Mehmet Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Öztürk, Derya Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Kalkan, Ali Kemal Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Yalcin, Ahmet Arif Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Akturk, İbrahim Faruk Mehmet Akif Ersoy Thoracic and Cardiovascular Research Hospital - Dept Cardiology, Turkey , Surgit, Özgür Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Tosu, Aydın Rodi Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey , Birand, Ali Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research Hospital - Dept Cardiology, Turkey
Abstract :
Objective: In the pathophysiology of rheumatic heart valve disease, chronic systemic inflammatory process plays an important role. In this study, we aimed to investigate whether the percutaneous transluminal mitral balloon valvuloplasty (PTMV) has any effect on the chronic systemic inflammatory response in patients with rheumatic mitral stenosis (RMS).Methods: In this study, we used neutrophil to lymphocyte ratio (NLR), which is a simply available and inexpensive biomarker of systemic inflammatory response, to evaluate the level of inflammation. A total of 41 consecutive patients with severe RMS undergoing successful PTMV were included in the study. Laboratory assessments of all patients by the measuring of NLR before and after the PTMV procedure were performed.Results: Before and after the PTMV, the mean lymphocyte counts were found 2.1±0.6 x103 /μL and 1.9±0.6 x103 / μL (p=0.01), and the mean leukocyte counts were 4.8±1.4 x103 /μL and 4.4±1.3 x103 /μL (p=0.069) respectively. NLR values were determined as 2.7 ± 1.0 and 2.2 ± 0.8. After the PTMV, there was a significant decrease in NLR in patients with rheumatic mitral stenosis patients (p=0.001). In the correlation analysis, there was significant negative correlation between the mitral valve area and NLR (p= 0.004- r=0.440), and there was significant positive correlation between left atrial diameter and NLR (p=0.028 r=0.344).Conclusion: This study showed significant decrease in NLR after PTMV in patients with RMS, which means reduced inflammation after PTMV. Larger studies are needed to confirm the results.
NaturalLanguageKeyword :
Rheumatic mitral stenosis , neutrophil , to , lymphocyte ratio , percutaneous mitral valvuloplasty , inflammation
