Evaluation of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Rheumatoid Arthritis

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Objective: The purpose of this study is to investigate the relationship of disease activity with Neutrophil-Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) and red blood cell distribution width (RDW). Methods: Seventy seven RA patients and 97 healthy subjects were examined retrospectively. People with chronic and systemic diseases were excluded from control group of the study. The disease activity scores (DAS 28) of patient group, hematologic parameters and inflammation parameters of both groups were analyzed statistically using independent t-test and spearman correlation test. Results: Age and gender was not found different between groups. CRP and ESR levels were significantly higher in RA group (p 0.001). Hemoglobin and platelet count were lower (p 0.001 and p=0.022), while RDW, NLR, PLR and MPV levels were significantly higher in RA group (p 0.001, p 0.001. p 0.001, p 0.001, respectively). In patient group, ESR (p 0.001), lymphocytes (%) (p= 0.042), absolute neutrophil (p=0.047), and platelets (p= 0.019) were positively, whereas lymphocytes were negatively affected by improvement disease activity (DAS 28) scores. PLR levels significantly negatively correlated with MPV levels (r= -0.386) but showed a significant positive correlation with RDW (r= 0.354) and NLR levels (r= 0.618). Conclusion: NLR and PLR are important and promising factors for disease activity estimation of rheumatoid arthritis and may be used in clinical practice. In our opinion, larger studies consisting larger group will help determination of disease activity of RA by more specific indices using these parameters.

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Neutrophil , lymphocyte ratio (NLR) , Platelet Lymphocyte Ratio (PLR) , Red blood cell distribution width (RDW) , Rheumatoid arthritis (RA) , İnflammation

Dicle Medical Journal

247

Dicle Medical Journal