Rustemoglu, Aydın Gaziosmanpasa University - Faculty of Medicine - Department of Medical Biology, Turkey , Cumurcu, Birgul Elbozan Inonu University - Faculty of Medicine - Department of Psychiatry, Turkey , Nursal, Ayse Feyda Giresun University - Faculty of Medicine - Department of Medical Biology, Turkey , Balkan, Mahmut Dicle University - Faculty of Medicine - Department of Medical Biology, Turkey , Uzun, Melike Gaziosmanpasa University - Faculty of Medicine - Department of Medical Biology, Turkey , Yigit, Serbulent Gaziosmanpasa University - Faculty of Medicine - Department of Medical Biology, Turkey

Adenosine Deaminase Gene G22a Polymorphism as a Risk Factor for Schizophrenia in Turkish Population

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Objective: The aim of this study was to investigate whether the G22A polymorphism of adenosine deaminase (ADA) gene is associated with schizophrenia in Turkish population.Methods: In this study, we evaluated 113 patients with schizophrenia and 121 individuals without the disease. The ADA G22A polymorphism was examined using allele specific-polymerase chain reaction (PCR).Results: The ADA G22A genotype frequencies of GG, GA, and AA were 79.3% (96/121), 20.7% (25/121) and 0% (0) in the control group, while 87.6 % (99/113), 10.6% (12/113), 1.8% (2/113) in the patient group, respectively. There was a statistically significant difference in genotype distribution between patients and controls (p=0.017). Also the frequency of GA genotype was found significantly lower in patients compared with healthy controls (OR = 0.46, 95% Cl 0.22-0.96, p =0.048). However, there was not any noticeable difference in allele distribution between the groups (p 0.05). In addition, the frequency of GG genotype in the male patient group significantly higher, and GA genotype significantly lower compared to the male control group, were found (p=0.036, p=0.005, respectively). No association was found for the female group.Conclusion: Our results show that, the G22A polymorphism of ADA gene may be associated with schizophrenia in Turkish population. The ADA GA genotype is likely to reduce, whereas GG genotype increased genetic susceptibility to schizophrenia, especially in males. Further studies should be repeated with different study subjects and/or other ethnic subjects to generalize the conclusion of this study.

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Schizophrenia , ADA gene , G22A polymorphism.

Dicle Medical Journal

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