Author/Authors :
Göknar, Nilüfer Bezmialem Vakıf Üniversitesi - Çocuk Nefroloji, Turkey , Göknar, Nilüfer Bağcılar Eğitim ve Araştırma Hastanesi - Çocuk Nefroloji, Turkey , Küçükkoç, Mehmet Nizip Devlet Hastanesi - Çocuk Sağlığı Hastalıkları, Turkey , Demir, Ayşegül Doğan Bezmialem Vakıf Üniversitesi - Çocuk Sağlığı ve Hastalıkları, Turkey , Vehapoğlu, Aysel Bezmialem Vakıf Üniversitesi - Çocuk Sağlığı ve Hastalıkları, Turkey , Öktem, Faruk Bezmialem Vakıf Üniversitesi - Çocuk Nefroloji, Turkey
Abstract :
Objective: The importance of mean platelet volume (MPV) in chronic inflammation was demonstrated in many diseases. We aimed to evaluate the role of MPV in nephrotic syndrome of childhood and relation with steroid response.Methods: We enrolled 59 children with nephrotic syndrome (24 steroid-resistance and 35 steroid-sensitive) and 34 healthy controls into the study. We evaluated total cholesterol, proteinuria, CRP, and albumin from study group and MPV and platelet count from both control and study group.Results: MPV level was higher in children with nephrotic syndrome when compared with control (8.6 ± 1.39 fl versus 7.09 ± 0.96 fl, p 0.001). Also platelet count was elevated in study group (406.092 ± 125.891 / μl versus 321.382 ± 78.666 / μl, p 0.001). MPV level and platelet count was similar in control and study subjects (p=0.798 and p=0.56).Conclusion: We demonstrated elevated MPV and platelet count in children with nephrotic syndrome. MPV is cheap, simple and important method to demonstrate platelet activation in nephrotic syndrome.
