مرکز منطقه ای اطلاع رساني علوم و فناوري - Radical Prostatectomy In High-Risk Prostate Cancer

Abstract :

Objective: There are some treatment choices such as surgery and radiotherapy in the treatment of high-risk prostate cancer. Today, some centers prefer surgical procedures in high-risk group due to increasing surgical experience. In our clinic, we evaluated the functional and oncological outcomes of patients who underwent open radical prostatectomy in high-risk prostate cancer. Methods: Data on 203 patients underwent radical prostatectomy between February 2011 and February 2015 were investigated. There were 20 cases in high-risk group. Characteristics and demographic datas of these patients were collected retrospectively. The characteristics of high-risk patients with other risk cases were compared statistically. Parameters associated with biochemical recurrence were examined in high-risk patients. Results: Mean age of patients was 63.1 years (range 56-69 years), the average PSA level were 14.2 ng / ml (range 9-46 ng / mL) and median follow-up was 27.85 months in high-risk prostate cancer. Biochemical recurrence was detected in 11 cases (55%). A statistically significant correlation was seen biochemical recurrence between seminal vesicle invasions in high-risk patients. Conclusion: Surgical options should be first preference in high-risk patients considering age, co-morbidity and patients choice in the result of these findings. Gleason score is the most important factor in predicting oncological outcomes and organ-confined disease may be in 20% of clinical stage T3. There is no significant difference between high risk and low risk patients in oncologic and functional outcomes but should be kept in mind additional treatment may need after surgery