SARIKAYA, Muhsin Afyon Kocatepe Üniversitesi - Fen Edebiyat Fakültesi - Kimya Bölümü, Turkey , ENGİNAR, Hüseyin Afyon Kocatepe Üniversitesi - Fen Edebiyat Fakültesi - Kimya Bölümü, Turkey

Radio Labeling of 2-Aminonicotinic Acid with 131I and Biodistribution on the Albino Wistar Rats

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Türk In this study, labeling of 2-aminonicotinic acid (2-ANA) with 131I, radiolabeling efficiency, the effect of pH and oxidizing agent on the labeling yield, in vitro stability and biodistribution of radiolabelling substance were made. Electrophoresis and Radio Thin Layer Chromatography (RTLC) methods were used in the quality control study of radiolabeled substance (131I-2-ANA). Biodistribution studies were done in nine male Albino Wistar rats which were categorized 3 groups. The rats were sacrificed at various time intervals (15, 60 and 180 min), their organs were removed, and percentage of injected dose per gram (% ID/g) was calculated. The labeling yield of 2-ANA was determined as % 86.41±3.11. Maximum uptake of 131I-2-ANA was seen in the stomach, kidneys, pancreas, liver, thyroid small intestine and fat. We concluded that the binding efficiency of 131I-2-ANA was high and it had sufficient stability for diagnostic studies.

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2 , Aminonicotinic acid , Biodistribution , 131I , Rat

Afyon Kocatepe University Journal Of Science an‎d Engineering

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