Author/Authors :
YENİKAYA, Cengiz Dumlupınar Üniversitesi - Fen-Edebiyat Fakültesi - Kimya Bölümü, Turkey , İLKİMEN, Halil Dumlupınar Üniversitesi - Fen-Edebiyat Fakültesi - Kimya Bölümü, Turkey , DEMİREL, Mehmet Melih Dumlupınar Üniversitesi - Fen-Edebiyat Fakültesi - Kimya Bölümü, Turkey , CEYHAN, Burçin Dumlupınar Üniversitesi - Fen-Edebiyat Fakültesi - Kimya Bölümü, Turkey , TUNCA, Ekrem Dumlupınar Üniversitesi - Fen-Edebiyat Fakültesi - Biyokimya Bölümü, Turkey , BÜLBÜL, Metin Dumlupınar Üniversitesi - Fen-Edebiyat Fakültesi - Biyokimya Bölümü, Turkey
Title Of Article :
Synthesis and Structural Studies of Proton Transfer Salt Between Benzimidazole and (E)-4-oxo-4-(4-sulfamoylphenylamino)but-2-enoic Acid and Their Transition Metal Complexes, and Investigation of Inhibition Properties on hCAI and hCA II Isoenzymes
Abstract :
In this study, first (E)-4-oxo-4-(4-sulfamoylphenylamino)but-2-enoic acid (Hsamal) have been synthesized from the reaction between sulfanilamide (sa) and maleic anhydride (mal) and second, proton transfer salt (Hapsamal) has been prepared from 2-aminopyridine (ap) and Hsamal. Four transition metal complexes [Fe(II), Co(II), Ni(II) and Zn(II)] of the salt have also been synthesized. The structure of proton transfer compounds have been proposed by using elemantal analysis, 1H-NMR, 13C-NMR, FT-IR, UV-Vis techniques. The structure of amorphous metal complexes have been proposed by using elemantal analysis, ICP-OES, FT-IR, UV-Vis, magnetic susceptibility and molar conductivity techniques. In addition, in vitro studies have been performed to determine the inhibition effects of synthesized compounds on human erythrocyte hCA I and hCA II isoenzymes. It has been observed that synthesized compounds have affected esterase activities of hCA I and hCA II and the inhibition values of these compounds are comparable with the inhibition values of control compound acetazolamide (AAZ).
NaturalLanguageKeyword :
“Sulfamoyl Compounds” “2 , Aminopyridine” “Proton Transfer Salt” “Metal Complexes” “Carbonic Anhydrase Inhibition”
JournalTitle :
Afyon Kocatepe University Journal Of Science and Engineering
