Author/Authors :
Sebbar, Nada Kheira Université Mohammed V - Faculté des Sciences - Laboratoire de Chimie Organique Hétérocyclique, Pharmacochimie, Morocco , Ellouz, Mohamed Université Mohammed V - Faculté des Sciences - Laboratoire de Chimie Organique Hétérocyclique, Pharmacochimie, Morocco , Zerzouf, Abdelfettah Ecole Normale Supérieure-ENS Takaddoum - Laboratoire de Chimie Organique et Etudes Physico-chimique, Morocco , Essassi, El Mokhtar Université Mohammed V - Faculté des Sciences - Laboratoire de Chimie Organique Hétérocyclique, Pharmacochimie, Morocco
Title Of Article :
SYNTHESIS OF NEW [1,4]-BENZOTHIAZINE DERIVATIVES
Abstract :
A synthesis of new heterocyclic systems containing [1,4]-benzothiazine moiety has been established. The condensation of 2- aminothiophénol 1 with 2-chloroacetic acid lead to 3,4-dihydro-2H-[1,4]-benzothiazin-3-one 2. Thereafter, the compound 2 is subjected to the action of benzaldehyde in the presence of an excess of sodium methoxide in DMF. This reaction led to the formation of 2-(benzylidene)-3,4-dihydro-2H-[1,4]-benzothiazin-3-one 3. Then, Nalkylation of the latter compound was accomplished using carbon chains halogenated under phase transfer catalysis conditions. The different products were obtained in good yields and their structures have been characterized by the usual spectroscopic methods.
NaturalLanguageKeyword :
[1 , 4] , benzothiazine , PTC , alkylation
JournalTitle :
Journal Marocain De Chimie Hétérocyclique
