Author/Authors :
Sebbar, Nada Kheira Université Mohammed V - Faculté des Sciences - Laboratoire de Chimie Organique Hétérocyclique URAC 21, Pharmacochimie, Maroc , Mekhzoum, M. El Mehdi Université Mohammed V - Faculté des Sciences - Laboratoire de Chimie Organique Hétérocyclique URAC 21, Pharmacochimie, Maroc , Mekhzoum, M. El Mehdi Moroccan Foundation for Advanced Science, Innovation and Research (MASCIR), Morocco , Essassi, El Mokhtar Université Mohammed V - Faculté des Sciences - Laboratoire de Chimie Organique Hétérocyclique URAC 21, Pôle de Compétences Pharmacochimie, Morocco , Essassi, El Mokhtar Moroccan Foundation for Advanced Science, Innovation and Research (MASCIR), Morocco , Abdelfettah, Zerzouf Ecole Normale Supérieure-ENS Takaddoum - Laboratoire de Chimie Organique et Etudes Physico-chimique, Morocco , Ouzidan, Younes Université Sidi Mohamed Ben Abdallah - Faculté des Sciences et Techniques - Laboratoire de Chimie Organique Appliquée, Maroc , Kandri Rodi, Youssef Université Sidi Mohammed Ben Abdallah - Faculté des Sciences et Techniques - Laboratoire de Chimie Organique Appliquée, Maroc , Talbaoui, Ahmed Université Mohammed V-Agdal - Faculté des Sciences - Laboratoire de Biochimie et Immunologie, Morocco , Bakri, Youssef Université Mohammed V-Agdal - Faculté des Sciences - Laboratoire de Biochimie et Immunologie, Morocco
Title Of Article :
SYNTHESIS MODELING AND ANTIBACTERIAL ACTIVITY OF NOVEL 1,2,3-TRIAZOLYLMETHYL-1,4-BENZOTHIAZINE DERIVATIVES
Abstract :
Due to the importance of heterocyclic systems containing triazole ring. a novel 1,2,3-triazolylmethyl-1,4-benzothiazine derivatives have been synthesized employing both 1,3-dipolar cycloaddition and the click chemistry approach. The structures of these compounds have been elucidated by spectral NMR analysis and confirmation of products was achieved by X-ray diffraction. Further experiments following the DFT study was also performed on these compounds. Moreover, all the synthesized compounds were subjected to in vitro biological evaluation. The various test carried out showed significant antibacterial activities against different microorganisms.
NaturalLanguageKeyword :
1,2,3 , triazole , 1,4 , benzothiazine , 1,3 , dipolar cycloaddition , DFT , antibacterial
