Şengül, İlker Giresun Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Turkey , Şengül, Demet Prof. Dr. A. İlhan Özdemir Devlet Hastanesi - Patoloji Kliniği, Turkey

Intracellular signalization and adenosine as mechanisms of ischemic preconditioning and post conditioning

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Ischemia reperfusion injury is the series of pathophysiological changes occurring in consequence of recirculation in the deoxygenated tissue. The potential mechanism of ischemia reperfusion injury includes tissue hypoxia, free oxygen radicals arising from the course of reperfusion, and inflammatory mediators. Primary ischemic injury appears as a consequence of accumulation of end products and toxic products of anaerobic metabolism which is occurred by insufficient circulation. But, in the concept of reperfusion injury; free oxygen radicals directly causes tissue injury via affecting themselves and producing inadequacy of cellular antioxidant systems. In ischemic pre - conditioning, locally released agonists trigger signalization way via activating receptors which are bounded to G protein. The adaptation via ischemic pre - conditioning is created by activation of KATP (Potassium-ATP) channels by the effect of adenosine. In the aspect of ischemic post - conditioning; it is propounded that this phenomenon depends on activation of mitochondrial KATP channels and ERK ½ (extracellular signal-regulated kinase cascade) and production of NO (Nitric oxide) and for the protective effect of the mentioned phenomenon, adenosine receptors are used and activation of PI3 (phosphatidyl inositol3) - kinase and guanylyl cyclase are needed.

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Adenosine , intracellular signalization , ischemic , preconditioning , post conditioning.

Cumhuriyet Medical Journal

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