Author/Authors
Katrancıoğlu, Nurkay Cumhuriyet University - School of Medicine - Department of Cardiovascular Surgery, Turkey , Manduz, Şinasi Cumhuriyet University - School of Medicine - Departments of Cardiovascular Surgery, Turkey , Karahan, Oğuz Cumhuriyet University - School of Medicine - Departments of Cardiovascular Surgery, Turkey , Kılıç, Ahmet Turan Cumhuriyet University - School of Medicine - Departments of Cardiovascular Surgery, Turkey , Berkan, Öcal Cumhuriyet University - School of Medicine - Department of Cardiovascular Surgery, Turkey
Title Of Article
The myocardial infarction in a young woman with heterozygous MTHRF and PAI-1 gene mutations.
شماره ركورد
32964
Abstract
Myocardial infarction in young patient accounts for 6% of all myocardial infarctions. Unlike older patients, the cause of the myocardial infarction in approximately 20% of young patients is not related to atherosclerosis. In this study, we report a case of myocardial infarction at a young woman who do not have classical risk factors for coronary artery disease, however, who was heterozygous for the methylene tetrahydrofolate reductase C677T/G gene mutation and plasminogen activator inhibitor- 1 4G/5G gene variant. Urgent coronary angiography revealed multi-vessel coronary disease, severe stenosis of the proximal left anterior descending artery, total occlusion of the first diagonal artery, and severe stenosis of the proximal circumflex artery. The lesions were thought to be not suitable for percutaneous revascularization and coronary by-pass surgery was performed. The postoperative course was uneventful and she was discharged on 8th day. In conclusion, coronary artery disease in young patient especially without classical risk factors, we suggest that prothrombotic factors should be evaluated.
From Page
257
NaturalLanguageKeyword
Myocardial infarction , young patient , gene polymorphism
JournalTitle
Cumhuriyet Medical Journal
To Page
259
JournalTitle
Cumhuriyet Medical Journal
Link To Document