Author/Authors :
Albayrak, Baki Serdar Süleyman Demirel University - School of Medicine - Department of Neurosurgery, Turkey , İsmailoğlu, Özgür Süleyman Demirel University - School of Medicine - Department of Neurosurgery, Turkey , Kabataş, Serdar Başkent University Hospital - Department of Neurosurgery, Turkey , Yılmaz, Cem Başkent University Hospital - Department of Neurosurgery, Turkey , Civelek, Erdinç Başkent University Hospital - Department of Neurosurgery, Turkey , Gülümser, Çağrı Nallıhan State Hospital - Department of Obstetrics and Gynecology, Turkey
Abstract :
CD133 and CD44 are widely expressed cell-surface markers in glioblastoma multiforme (GBM) and meningiomas respectively. Recent molecular studies revealed that CD133-positive GBM cells have cancer stem cell features with self-renewal and self-recapulating capacity. Similarly, it is also known that CD44 is expressed differentially on various meningioma subtypes and several studies in the literature reported that CD44 expression is correlated with the invasiveness of meningiomas. In this context, we aimed to highlight the expression patterns of CD133 and CD44 and their implications with the potential cancer stem cells in glioblastoma multiforme (GBM) and meningiomas, respectively.
NaturalLanguageKeyword :
Glioma , meningioma , cancer stem cell , CD133 , CD44
