Abstract :
In this case, the mass taken from the vagina of a cross breed, adult bitch was examined histopathologically and immunohistochemically. The mass is 10x5x3 cm in size, 75 g in weight and in the outlook the view of the mass is multilobular, reddish-black, gray and white colors from place to place. There were circular, thin linear bands on its cut-surface and also some areas contained reddish-black necrotic tissue. On the microscopic examination swollen spindle-shaped, sausage-like, pleomorphic neoplastic cells were observed. These neoplastic cells invaded far into to muscle tissue. Giant cells and mitotic figures were observed in a large number of microscopic areas. In the immunohistochemical staining, cytoplasms of these neoplastic cells with anti-vimentin antibody are stained and with anti-cytokeratin, anti-desmin and anti-smooth muscle actin antibodies aren’t stained. In terms of proliferation markers (anti-PCNA, anti-Ki-67), immunohistochemically positive, a large number of positive cells were observed. The mass was diagnosed as a fibrosarcoma. In conclusion, due to the fact that vaginal fibrosarcoma are very rarely seen in dogs, we think that its pathomorphologic and immunohistochemical findings will contribute to the literature in this area.
