Özer, Hatice Cumhuriyet Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Tuncer, Ersin Cumhuriyet University - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Çiftçi, Ayşe Cumhuriyet Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Keser, Hande Cumhuriyet Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Aker, Handan Cumhuriyet Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Elagöz, Şahande Cumhuriyet University - School of Medicine - Department of Pathology, Turkey , Boztosun, Abdullah Cumhuriyet Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey

Distribution of cytological diagnoses in cervical smears with epithelial cell abnormality and cyto-histopathological correlation

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Aim. To evaluate the cervicovaginal smears with epithelial cell abnormality examined in our department and to investigate the cyto-histopathological correlation of these cases with their histopathological diagnoses. Method. The reports of cervical smears diagnosed according to 2001 Bethesda System in Cumhuriyet University, Faculty of Medicine, Pathology Department between January 2008 and May 2011 were reviewed retrospectively (n: 8102). Among them, cases with epithelial cell abnormality (n: 97) were included in the study. In 25 of these patients having also histopathological examinations, cyto-histopathological correlation was investigated. . Results. Epithelial cell abnormality was detected in 97 (1.19) out of 8102 cervical smears. In the cytopathological examination, 54 patients (55.6%) had ASC-US, 14 had (14.4%) ASC-H, 14 had (14.4%) LSIL, five had (5.2%) HSIL, five had (5.2%) squamous cell carcinoma (SCC), three had (3.1%) atypical glandular cells (AGC) and two had (2.1%) adenocarcinoma, NOS. Histopathological results of 25 patients revealed that 10 patients had (40%) nonneoplastic, two had CIN I (8%), one had (4%) CIN II, three had (12%) CIN III and nine had (36%) malignant lesion. The positive predictive values for the cases with diagnoses of ASC-US, ASC-H, LSIL, HSIL, SCC, AGC and adenocarcinoma were 0%, 50%, 100%, 80%, 100%, 0% ve 100%, respectively. Conclusion. Eventhough the positive predictive values in diagnosis of carcinoma, HSIL, and LSIL had been high, those values were found to be low in diagnosis of ASC-US and AGC in our series, but since the number of follow-up cases were very few in these groups this result was accepted as not reliable.

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Cervical smear , cyto , histopathological correlation , epithelial cell abnormality

Cumhuriyet Medical Journal

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