Adaptive splenic radiation in a case of idiopathic myelofibrosis

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Idiopathic myelofibrosis is a chronic myeloproliferative disorder. Chronic myeloprolipherative disorders are clonal stem cell disorders associated with myeloid cell growth . Extramedullary hematopoiesis in the bone marrow deficiency and increased erythropoiesis resultin massive splenomegaly which then lead to anemia and abdominal discomfort which are major causes of morbidity in these cases. Splenic radiotherapy is recommended for palliation of symptoms such as abdominal pain, anemia and thrombocytopenia due to massive splenomegaly. In this study, a 59-year-old male patient with a diagnosis of idiopathic myelofibrosis was evaluated. Splenic radiotherapy was applied to him in 2 fractions per week with increasing doses for a total of 6 fractions as he had massive splenomegaly, severe pain requiring narcotic analgesic use, and had repeated need for transfusion caused by severe thrombocytopenia due to hypersplenism His abdominal pain palliation was achieved by 100% after treatment. . Splenic radiotherapy should be considered as an effective treatment modality for palliative treatment of symptomatic splenomegaly.

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Idiopathic myelofibrosis , splenomegaly , splenic radiotherapy

Cumhuriyet Medical Journal

368

Cumhuriyet Medical Journal